Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-526-0 | CAS number: 107-85-7
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Primary aliphatic amines do not hydrolyze under ambient conditions
Key value for chemical safety assessment
Additional information
In amines the bond between the terminal (saturated) carbon atom and the nitrogen atom (single bond) is polarized with a positive partial charge at the carbon atom. The positively charged carbon atom is in principle capable to undergo nucleophilic substitution with an electron rich species (for example strong bases). Water exhibits nucleophilic properties, but it is not a strong enough nucleophile to generate an efficient reaction with amines under ambient conditions. The energy barrier for the nucleophilic substitution reaction is too high to be overcome.
Thus there is no hydrolytic degradation of amines in aqueous environmental compartments under ambient conditions (GUBDH, 2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
