Reaction mass of (2-methoxymethylethoxy)propanol and [2-(2-methoxymethylethoxy)methylethoxy]propanol and sodium methanolate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

1962

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Older study, widely cited and used on many compounds for acute toxicity assessments. Article provides minimal but sufficient methodological detail.

Data source

Reference

Reference Type:

publication

Title:

Range-finding toxicity data: List VI

Author:

Smyth, H.F. et al.

Year:

1962

Bibliographic source:

American Industrial Hygiene Association Journal, 23:95-107.

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

Study was done prior to GLP

Test type:

standard acute method

Limit test:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Type:

Constituent

Details on test material:

None provided in the article

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

Age at start: 4-5 weeks
Weight: 90-120 g
Diet: Rockland rat diet, complete

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Undiluted material was used, followed by 2-fold dilutions in water if lower doses were necessary.

Mortalities were noted during a 14-day follow up period.

Doses:

Not specified

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

Animals were dosed once by oral gavage with undiluted test material, and aqueous dilutions if needed. The LD50 was calculated based on total mortalities observed within a 14-day follow up period.

Statistics:

LD50 was calculated using the method of Weil (Biometrics 8:249, 1952).

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

5.66 mL/kg bw

Remarks on result:

other: 5380 mg/kg based on a specific gravity of 0.951

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: OECD GHS

Conclusions:

DIpropylene glycol monomethyl ether (DPM) was administered by single oral gavage to groups of 5 male rats, and mortality followed for 14 days. The calculated LD50 was 5.66 mL/kg (5380 mg/kg).