Registration Dossier
Registration Dossier
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EC number: 266-257-8 | CAS number: 66215-27-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1991/10/09 to 1992/05/05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- This experimental study report is reliable as it has been conducted by a trusted laboratory, under GLP and following OECD Guidelines.
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal Register 40 CFR part 796.1840
- Version / remarks:
- 1985
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 8 g/L
- Temp.:
- 25 °C
- pH:
- 5.3
- Key result
- Water solubility:
- 13 g/L
- Temp.:
- 25 °C
- pH:
- 9
- Key result
- Water solubility:
- 13 g/L
- Temp.:
- 25 °C
- pH:
- 7.1
- Conclusions:
- The solubility of the test substance was determined to be 13 g/L at pH 7.1 and 25 °C; 13 g/L at pH 9.0 and 25 °C; 8.0 g/L at pH 5.3 and 25 °C (as phosphate salt).
- Executive summary:
The water solubility of the test substance has been determined using a flask method. The study was perfomed in accordance with the OECD Guideline 105 and US Federal Register 40 CFR part 796.1840. The solubility of the pure active ingredient in buffered aqueous solutions was determined to be 13 g/L at pH 7.1 and 25 °C; 13 g/L at pH 9.0 and 25 °C; 8.0 g/L at pH 5.3 and 25 °C (as phosphate salt).
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001/07/30 to 2001/08/16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 13 g/L
- Conc. based on:
- act. ingr.
- Temp.:
- 25 °C
- pH:
- 7.9
- Conclusions:
- The solubility of test substance determined at 25 °C and pH 7.9 in the pure water is 13 g/L.
- Executive summary:
The water solubility of the test substance has been determined using a flask method. The study was perfomed in accordance with the OECD Guideline 105, EU Method A.6 and EPA OPPTS 830.7840. The water solubility of the test substance at 25 °C and pH 7.9 in the pure water is 13 g/L.
Referenceopen allclose all
Description of key information
The water solubility of the test substance has been determined using a flask method. The study was perfomed in accordance with the OECD Guideline 105, EU Method A.6 and EPA OPPTS 830.7840. The water solubility of the test substance at 25 °C and pH 7.9 in the pure water is 13 g/L.
Key value for chemical safety assessment
- Water solubility:
- 13 g/L
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
