Registration Dossier
Registration Dossier
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EC number: 439-590-3 | CAS number: 12158-75-7
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- n.a.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no glp information
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 7758-99-8
- Cas Number:
- 7758-99-8
- IUPAC Name:
- 7758-99-8
- Reference substance name:
- copper sulfate pentahydrate
- IUPAC Name:
- copper sulfate pentahydrate
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- n.a.
- Frequency of treatment:
- once
- Post exposure period:
- 24 an 48 h
Doses / concentrationsopen allclose all
- Dose / conc.:
- 6.6 mg/kg bw/day (nominal)
- Remarks:
- Doses / Concentrations:
6.6
Basis:
other: mg / kg bw
- Dose / conc.:
- 13.2 mg/kg bw/day (nominal)
- Remarks:
- Doses / Concentrations:
13.2
Basis:
other: mg / kg bw
- Dose / conc.:
- 19.8 mg/kg bw/day (nominal)
- Remarks:
- Doses / Concentrations:
19.8
Basis:
other: mg / kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, historical
- Positive control(s):
- -
Examinations
- Tissues and cell types examined:
- Bone narrow; ratio of plychromatic and normocytes
- Details of tissue and slide preparation:
- --
- Evaluation criteria:
- -
- Statistics:
- -
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- at dose levels over 6.6 mg / kg bw
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- -
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
copper sulfate pentahydrate is inactive mouse bone-norrow micronucleus assay - Executive summary:
-
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