Registration Dossier
Registration Dossier
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EC number: 947-896-8 | CAS number: -
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- GLP compliance:
- no
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch Number S5690
- Expiration date of the lot/batch: Not specified
- Purity test date: Not applicable - Key result
- Decomposition:
- yes
- Decomp. temp.:
- ca. 116 °C
- Conclusions:
- Three mildly exothermic events were observed with onset temperatures of 116.7°C, 210.0°C and 237.7°C, the normalized energy outputs being 27.6, 8.4 and 7.7 J/g respectively. This profile is indicative of gradual sample decomposition.
- Executive summary:
The boiling point and thermal staibity of Escherichia Coli dehalogenase powder was evaluated by Differential Scanning Calorimetry. Three mildly exothermic events were observed with onset temperatures of 116.7°C, 210.0°C and 237.7°C, the normalized energy outputs being 27.6, 8.4 and 7.7 J/g respectively. This profile is indicative of gradual sample decomposition. No thermal event that could be attributed to melting or boiling points was observed.
The DSC plot for the substance is attached as Plot 1 below.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- GLP compliance:
- no
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- Unknown 6
- IUPAC Name:
- Unknown 6
- Reference substance name:
- Unknown 7
- IUPAC Name:
- Unknown 7
- Reference substance name:
- Unknown 5
- IUPAC Name:
- Unknown 5
- Reference substance name:
- Unknown 4
- IUPAC Name:
- Unknown 4
- Reference substance name:
- Unknown 3
- IUPAC Name:
- Unknown 3
- Reference substance name:
- Unknown 2
- IUPAC Name:
- Unknown 2
- Reference substance name:
- Unknown 1
- IUPAC Name:
- Unknown 1
- Test material form:
- solid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: S5690
- Expiration date of the lot/batch: Not specified
- Purity test date: Not specified
Results and discussion
Melting / freezing point
- Key result
- Decomposition:
- yes
- Remarks:
- Three mildly exothermic events were observed with onset temperatures of 116.7°C, 210.8°C and 237.7°C, the normalized energy outputs being 27.6, 8.4 and 7.7 J/g respectively. This profile is indicative of gradual sample decomposition.
- Remarks on result:
- not determinable
Any other information on results incl. tables
Please refer to Plot 1 attached to end point 4.3 Boiling Point.
Applicant's summary and conclusion
- Conclusions:
- Three mildly exothermic events were observed with onset temperatures of 116.7°C, 210.0°C and 237.7°C, the normalized energy outputs being 27.6, 8.4 and 7.7 J/g respectively. This profile is indicative of gradual sample decomposition, no exothermic event that could be attributed to melting was observed.
- Executive summary:
The melting point and thermal stability of Escherichia Coli dehalogenase powder was evaluated by Differential Scanning Calorimetry. Three mildly exothermic events were observed with onset temperatures of 116.7°C, 210.8°C and 237.7°C, the normalized energy outputs being 27.6, 8.4 and 7.7 J/g respectively. This profile is indicative of gradual sample decomposition. No thermal event that could be attributed to melting or boiling point was observed.
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