Registration Dossier
Registration Dossier
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EC number: 947-896-8 | CAS number: -
Explosiveness
Administrative data
- Endpoint:
- explosiveness, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11/03/2021-23/03/2021
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Key study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.14 (Explosive properties)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Unknown 6
- IUPAC Name:
- Unknown 6
- Reference substance name:
- Unknown 7
- IUPAC Name:
- Unknown 7
- Reference substance name:
- Unknown 5
- IUPAC Name:
- Unknown 5
- Reference substance name:
- Unknown 4
- IUPAC Name:
- Unknown 4
- Reference substance name:
- Unknown 3
- IUPAC Name:
- Unknown 3
- Reference substance name:
- Unknown 2
- IUPAC Name:
- Unknown 2
- Reference substance name:
- Unknown 1
- IUPAC Name:
- Unknown 1
- Test material form:
- solid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
- Specific details on test material used for the study:
- The material is composed of spray-dried cells of Escherichia coli BL21(DE3) expressing the dehalogenase enzyme. The Escherichia coli is grown in a fermenter on a nutrient medium mainly comprised of inorganic salts (including (NH4)SO2, K2HPO4, MgSO4 and FeSO4), yeast extract and glucose. In addition, SiO2 is added prior to spray drying. However, the final composition of the material is unknown due to the substance is to be registered as an UVCB (Unknown or Variable composition, Complex reaction products or Biological materials) and a definitive degree of purity cannot be determined.
Batch No.: 19111201045
Activity: 117 u/g Dehalogenase
Appearance: Beige/light brown solid
Storage conditions: Below -10 °C, dry
Results and discussion
Small-scale preliminary testsopen allclose all
- Key result
- Parameter:
- other: Thermal stability
- Remarks on result:
- other: The test item showed multiple exothermal signals. Maximum energy release of 350 J/g and 251 J/g were recorded in two DSC-measurements.
- Key result
- Parameter:
- sensitiveness to impact: impact energy (J)
- Value:
- 40
- Remarks on result:
- negative (not further specified)
- Key result
- Parameter:
- sensitiveness to friction: friction load (N)
- Value:
- 360
- Remarks on result:
- negative (not further specified)
- Key result
- Parameter:
- thermal sensitivity - Koenen test: diameter of the orifice plate
- Value:
- 2
- Remarks on result:
- negative (not further specified)
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Conclusions:
- The test showed only negative results.
The test item has no explosive properties in the sense of the European Commission Regulation (EC) No. 440/2008, method A.14. - Executive summary:
The test item contained inorganic substances and its composition was not completely known. Therefore, the main test on explosive properties according to European Commission Regulation (EC) No. 440/2008, method A.14. was performed. The test showed only negative results.
The test item had no explosive properties in the sense of the European Commission Regulation (EC) No. 440/2008, method A.14.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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