Citric acid, sodium titanium salt

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Citric acid, sodium titanium salt

EC Number:

273-399-4

EC Name:

Citric acid, sodium titanium salt

Cas Number:

68959-15-9

Molecular formula:

C6H8O7.xNa.xTi

IUPAC Name:

sodium titanium(2+) citrate

Specific details on test material used for the study:

Test Item Name TYZOR ACtivate 422
IUPAC Name Citric acid, sodium titanium salt
C.A. Name Information not provided by Sponsor
CAS Number 68959-15-9
Batch/Lot Number 334-300179/000009
Analysed Purity (Provided by Sponsor) As Ti: 2.13% w/w (Refer Certificate of Analysis in APPENDIX 2)
Appearance Pale yellow clear liquid
Manufactured by Dorf Ketal Speciality Catalyst Private Limited
Supplied to JRF by Dorf Ketal Speciality Catalyst Private Limited
Date of Manufacture August 2016
Date of Expiry August 2018

Results and discussion

Water solubility

Key result

Water solubility:

ca. 1 000 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 5 - <= 9

Any other information on results incl. tables

Preliminary Test

Different quantities of test item were weighed in triplicate (TABLE Below) and transferred into separate graduated test tubes and a preliminary estimation of solubility was made by adding buffer waters to the respective graduated test tubes at 20 ºC. The test item in all the test tube dissolved immediately as soon as a volume of 0.1 mL respective buffer water was added to the test tube. The result of the preliminary test was as described below:

Buffer Solution	Weight (g) of Test Item	Solubility Observed in (mL of Buffer)		Approx. solubility (g/L)
		Volume (mL) of buffer added	0.1
pH 5	0.1014	Solubility observed	Y	> 10^-2
pH 7	0.1002	Solubility observed	Y	> 10^-2
pH 9	0.1009	Solubility observed	Y	> 10^-2

 

Key: Y = Yes

Since the test item was highly soluble in all three graduated test tubes just after addition of 0.1 mL of respective buffer waters, the solubility of test item in buffer waters was recorded as > 10^-2g/L and therefore "shake flask method" was adopted to determine the solubility of TYZOR ACtivate 422 inbuffer waters.

Applicant's summary and conclusion

Conclusions:

 The solubility ofTYZOR ACtivate 422in all the buffer waters[viz. pH 5, 7 and 9],was > 1000 g/L at 20 °C.

Executive summary:

The solubility ofTYZOR ACtivate 422in all the buffer waters[viz. pH 5, 7 and 9],was > 1000 g/L           at 20 °C.