Registration Dossier
Registration Dossier
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EC number: 273-399-4 | CAS number: 68959-15-9
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- HYPOTHESIS FOR THE ANALOGUE APPROACH
There is a mechanistic reasoning to the read-across. The target substance, citric acid, sodium titanium salt (Tyzor Activate 422) hydrolyses rapidly upon contact with water or moisture. The complete hydrolysis will take place with no significant reaction products other than sodium citrate and hydrated titanium dioxide.
Therefore, read-across from the existing physicochemical studies (partition coefficient) on the source substance is considered as an appropriate adaptation to the standard information requirements of Annex VII of the REACH regulation.
ANALOGUE APPROACH JUSTIFICATION
Physicochemical data shows that the physicochemical profiles of the target and source substance are similar as outlined in the data matrix.
The target substance (Tyzor Activate 422) is hydrolytically unstable. Due to a rapid hydrolysis octanol-water partition coefficient is not technically feasible to test for the target substances. . Thus, partition coefficient n-octanol/water (Log Kow) of citric acid is used to improve the understanding on physico-chemical properties of the target substance. Due to a rapid hydrolysis citric acid data is used to fulfil endpoint requirements of self-ignition temperature.
DATA MATRIX
See IUCLID section 13.2. for data matrix
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- partition coefficient
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- HYPOTHESIS FOR THE ANALOGUE APPROACH
There is a mechanistic reasoning to the read-across. The target substance, citric acid, sodium titanium salt (Tyzor Activate 422) hydrolyses rapidly upon contact with water or moisture. The complete hydrolysis will take place with no significant reaction products other than sodium citrate and hydrated titanium dioxide.
Therefore, read-across from the existing physicochemical studies (partition coefficient) on the source substance is considered as an appropriate adaptation to the standard information requirements of Annex VII of the REACH regulation.
ANALOGUE APPROACH JUSTIFICATION
Physicochemical data shows that the physicochemical profiles of the target and source substance are similar as outlined in the data matrix.
The target substance (Tyzor Activate 422) is hydrolytically unstable. Due to a rapid hydrolysis octanol-water partition coefficient is not technically feasible to test for the target substances. . Thus, partition coefficient n-octanol/water (Log Kow) of citric acid is used to improve the understanding on physico-chemical properties of the target substance. Due to a rapid hydrolysis citric acid data is used to fulfil endpoint requirements of self-ignition temperature.
DATA MATRIX
See IUCLID section 13.2. for data matrix - Reason / purpose for cross-reference:
- read-across source
- Guideline:
- other: not specified
- Principles of method if other than guideline:
- no method descibed in the handbook
- GLP compliance:
- not specified
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -1.64
- Temp.:
- 20 °C
- pH:
- ca. 3
- Conclusions:
- A Log Kow value of -1.64 is reported for citric acid
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Handbook of Environmental Data on Organic Chemicals
- Author:
- Verschueren, K.
- Year:
- 1 983
- Bibliographic source:
- 2nd Edition. Van Nostrand Reinhold Company Inc., New York
Materials and methods
Test guideline
- Guideline:
- other: not specified
- Principles of method if other than guideline:
- No method was described
- GLP compliance:
- not specified
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Citric acid
- EC Number:
- 201-069-1
- EC Name:
- Citric acid
- Cas Number:
- 77-92-9
- Molecular formula:
- C6H8O7
- IUPAC Name:
- citric acid
Constituent 1
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -1.72
- Temp.:
- 20 °C
- pH:
- ca. 3
Applicant's summary and conclusion
- Conclusions:
- A Log Kow value of -1.72 is reported for citric acid
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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