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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Justification for type of information:
Water solubility measured as part of EC Physico/Chemical Test A5, Surface Tension (Ring Method).
Qualifier:
according to guideline
Guideline:
other: EU Regulation (EC) 440/2008, Annex Part A test A5 and OECD Test Guideline 115
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
Hop extract batch number 160025. This is a liquid carbon dioxide extract of hops variety 'Cascade'.
Key result
Water solubility:
< 1 mg/L
Conc. based on:
test mat.
Incubation duration:
ca. 3 h
Temp.:
20 °C
pH:
ca. 7
Details on results:
Two solutions were made up of the following dilutions: 10 mg per 10 ml and 1 mg per 1 litre. They were shaken and left for approximately 3 hours. After 30 minutes of sonication of the 1 mg per 1 litre solution the sample remained visible, therefore the sample's solubility is <1 mg per litre.
Conclusions:
Testing hop extract for surface tension revealed that the solubility of hop extract in water is less than 1 mg per litre. This is entirely as expected - hop extracts consist of poorly-soluble components (resins) and hydrophobic fractions (essential oils).
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Type of method:
flask method
Specific details on test material used for the study:
Variety Taurus, year 2015, Batch no. 15/67
Key result
Water solubility:
ca. 0 mg/L
Conc. based on:
act. ingr. (dissolved fraction)
Incubation duration:
ca. 48 h
Temp.:
40 °C
pH:
ca. 3.73
Details on results:
The extent of dissolution was assessed by measuring the active ingredients alpha acids and beta acids by HPLC. These were not detected.
Conclusions:
Endpoint Water solubility.001 shows that the solubility of hop extract in water is less than 1 mg per litre. This second endpoint confirms the low solubility of hop extract in water. This is entirely as expected - hop extracts consist of poorly-soluble components (resins) and hydrophobic fractions (essential oils). Some components may dissolve to some extent, but an overall solubility of <1 mg per litre for the whole UVCB is indicated.

Description of key information

Key value for chemical safety assessment

Water solubility:
1.6 mg/L
at the temperature of:
20 °C

Additional information

Hop extract is not soluble in water. Some components of the UVCB may dissolve to approximately 1.6 mg per litre as noted in the study report for endpoint 6.1.3. This number, viz. 1.6 mg per litre, is used for CSR, to account for certain components, bearing in mind that the solubility of the overall UVCB is negligible.