Dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

August - September 1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The restrictions were that only two animals were used at each dose level, and the report has limited detail.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

only two animals were used at each dose level, and the report has limited detail.

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

[2-(perfluorobutyl)ethyl]dichloro(methyl) silane

IUPAC Name:

[2-(perfluorobutyl)ethyl]dichloro(methyl) silane

Constituent 2

Reference substance name:

Dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane

EC Number:

253-930-6

EC Name:

Dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane

Cas Number:

38436-16-7

Molecular formula:

C7H7Cl2F9Si

IUPAC Name:

Dichloro(methyl)(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane

Details on test material:

[2-(perfluorobutyl)ethyl]dichloro(methyl)silane

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Breeding labs
- Age at study initiation: no information
- Weight at study initiation: 273-307 g
- Fasting period before study: overnight
- Housing: no information
- Diet (e.g. ad libitum): no information
- Water (e.g. ad libitum): no information
- Acclimation period: no information

ENVIRONMENTAL CONDITIONS: no information

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

0.316, 0.63, 1.26, 2.52 g/kg bw

No. of animals per sex per dose:

one male and one female per dose

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

890 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Result described as an ALD50 in study report.

Clinical signs:

Lethargy and ataxia, writing response, piloerection and prostration.

Body weight:

No significant reductions in food consumption or body weight gain in surviving animals.

Gross pathology:

No gross pathological alterations were observed in organs or tissues examined after terminal sacrifice of surviving animals.

Any other information on results incl. tables

Acute oral toxicity study: body weights and mortalities

Dose (gm/kg)	Body weight (g) on day								Mortality
	0	1	7	14	0	1	7	14	Animal found dead on day
	males				females				males	Females
0.316	304	297	344	388	227	243	256	263	-	-
0.63	293	315	344	389	228	248	247	248	-	-
1.26	280	263	-	-	242	-	-	-	2	0
2.52	283	280	-	-	232	-	-	-	1	0

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

[2-(perfluorobutyl)ethyl]dichloro(methyl)silane has been tested for acute oral toxicity according to OECD 401 and in compliance with GLP. Undiluted test material was administered by gavage to one male and one female rat per dose at 316, 630, 1260 and 2520 mg/kg bw. All animals administered 1260 and 2520 mg/kg bw died, the females on day 0 and the males on day 2. It is concluded that the LD50 is 890 mg/kg bw.