Registration Dossier
Registration Dossier
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EC number: 207-997-3 | CAS number: 504-63-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies in Detoxication
- Author:
- Gessner PK, Parke DV, and Williams RT
- Year:
- 1 960
- Bibliographic source:
- Bioch. 74:1-5
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- 4 rabbits were fed a 4 mmol/kg dose of the test substance. Urine was collected for 3 days after dosing. Urine was analysed daily for glucuronic acid.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propane-1,3-diol
- EC Number:
- 207-997-3
- EC Name:
- Propane-1,3-diol
- Cas Number:
- 504-63-2
- Molecular formula:
- C3H8O2
- IUPAC Name:
- propane-1,3-diol
- Details on test material:
- - Purity: Not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Chinchilla
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
Doses / concentrations
- Dose / conc.:
- 4 other: mmol/kg
- No. of animals per sex per dose / concentration:
- 4
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Glucuronic acid conjugation (% of dose): 1 (0-2)
Urinary metabolites characterized: None found
Any other information on results incl. tables
The test substance did not undergo glucuronic acid conjugation. No malonic acid was detected in the urine of rabbits. Three oxidation products of propane, 1,3-diol are possible, beta-hydroxypropionic aldehyde, beta-hydroxypropionic acid (hydracrylic acid) and malonic acid. Malonic acid can apparently be metabolized through the tricarboxylic acid cycle and recently malonyl-coenzyme A has been found to be an intermidiate in fatty acid synthesis. Hydroacrylic acid has also been reported to be metabolized in animal tissues. It appears probably that propane, 1,3-diol is oxidized completely to carbon dioxide in the body.
Applicant's summary and conclusion
- Conclusions:
- The test substance did not undergo glucuronic acid conjugation.
- Executive summary:
The test substance did not undergo glucuronic acid conjugation. No malonic acid was detected in the urine of rabbits. Three oxidation products of propane, 1,3-diol are possible, beta-hydroxypropionic aldehyde, beta-hydroxypropionic acid (hydracrylic acid) and malonic acid. Malonic acid can apparently be metabolized through the tricarboxylic acid cycle and recently malonyl-coenzyme A has been found to be an intermidiate in fatty acid synthesis. Hydroacrylic acid has also been reported to be metabolized in animal tissues. It appears probably that propane, 1,3-diol is oxidized completely to carbon dioxide in the body.
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