3,4-dimethoxyphenethylamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Principles of method if other than guideline:

Method: other: BASF-test.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,4-dimethoxyphenethylamine

EC Number:

204-376-9

EC Name:

3,4-dimethoxyphenethylamine

Cas Number:

120-20-7

Molecular formula:

C10H15NO2

IUPAC Name:

2-(3,4-dimethoxyphenyl)ethanamine

Details on test material:

- name of substance: homoveratrylamin
- Purity: 98 %
- substance number: 78/836
- appearance: clear, yellowish, slightly viscous liquid

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Gaukler
- Diet (e.g. ad libitum): Ssniff
- Weight at study initiation: mean 2.91 kg (4h); mean 2.8 kg (1h)

Test system

Type of coverage:

occlusive

Preparation of test site:

other: clipped

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin

Amount / concentration applied:

- about 1 g of the undiluted test substance was applied to an area of 2.5 x 2.5 cm.
- occlusive dressing
- no washing of the exposed area

Duration of treatment / exposure:

4 hour(s), 1 hour

Observation period:

8 days

Number of animals:

2 (4 h); 4 (1h)

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

other: 24 and 48 h

Score:

2

Max. score:

4

Reversibility:

other: observation period only 8 days

Results 2

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

other: 24 and 48 h

Score:

2.5

Max. score:

4

Reversibility:

other: observation period only 8 days

Results 3

Irritation parameter:

edema score

Basis:

other: animal #1 and #2

Time point:

other: 24 - 48 h

Score:

2

Max. score:

4

Reversibility:

other: observation period only 8 days

Remarks on result:

other: overall edema

Other effects:

- superficial necrosis observed on day 8 (animal #1).
- loose incrustation on day 8 (animal #2).

Any other information on results incl. tables

Animal No.	4 hour		1 day		2 days		8 days
	Erythema	Edema	Erythema	Edema	Erythema	Edema	Erythema	Edema
1	2	2	2 e	2 e	2 e	2 e	Nds	0
2	2	2	2 e	2 e	3 e	2 e	Cr	0

 

e: extending beyound the area of exposure

Nds: dot-like superficially necrosis

Cr: crust removable, intakt skin under

Animal No.	1 hour		1 day		2 days		8 days
	Erythema	Edema	Erythema	Edema	Erythema	Edema	Erythema	Edema
1	0	0	2	1	1	0	0 S	0
2	1	0	2 e sn	2 e	3 e sn	2	4 Np	2
3	1	1	2 e	3 e	2 e sn	2 e	0 S	0
4	1	1	2 e	3 e	2 e	2 e	0 S	0

 

e: extending beyound the area of exposure

sn: spotted necrotic-like skin areas

np: necrosis, parchment-like

S: scaling

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

Based on the results of this study, the test substance homoveratrylamin is highly irritating to skin.