Registration Dossier
Registration Dossier
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EC number: 204-376-9 | CAS number: 120-20-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable. Non-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other: BASF-test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Details on test material:
- I- name of substance: homoveratrylamin
- Purity: 98 %
- substance number: 78/836
- appearance: clear, yellowish, slightly viscous liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - food: Herilan MRH-Haltung; H. Eggersmann KG
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 50 and 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - fasting before application: 15-20 h
- observation period: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 160 mg/kg bw
- Mortality:
- Male animals:
- At the dose level of 200 mg/kg 1 animal was dead 2 days after administration and 4 had died after 14 days.
- At the lower dose level of 50 mg/kg no mortality was observed.
Female animals:
- At the dose level of 200 mg/kg 1 animal was dead 7 days after administration and 2 had died after 14 days.
- At the lower dose level of 50 mg/kg no mortality was observed. - Clinical signs:
- Dyspnoea, apathy, spasms, ruffled fur, dehydration, bad general condition.
- Body weight:
- Mean body weigts [g] before administration/2-4 days after/ 7 days after/ 13 days after administration
Male animals
- 200 mg/kg bw dose level: 24/21.7/19.0/27.0
- 50 mg/kg bw dose level: 26/30.0/29.0/32.2
Female animals
- 200 mg/kg bw dose level: 20/19.0/18.7/21.0
- 50 mg/kg bw dose level: 22/25.2/25.6/27.4 - Gross pathology:
- The animals which had died during the course of the study showed no findings at necropsy. The animals which survived until the end of the study showed an astringent liver serosa at necropsy.
Applicant's summary and conclusion
- Conclusions:
- Based on the results of this study, an intraperitonealy administered dose of 50 mg/kg bw homoveratrylamin was well tolerated by the test animals, whereas administration of 200 mg/kg bw yielded clear signs of toxicity, resulting in mortality of 66.7 % of the testing animals.
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