Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No GLP compliance and no compliance with guidelines, but it is a range finding study. Guinea pig is not the preferred species for classification.

Data source

Reference
Reference Type:
publication
Title:
Further experience with the range finding test in the industrial toxicology laboratory
Author:
Smyth H, Carpenter CP
Year:
1948
Bibliographic source:
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 63.

Materials and methods

Principles of method if other than guideline:
Range finding study
GLP compliance:
no
Test type:
other: range finding study

Test material

Constituent 1
Chemical structure
Reference substance name:
Aziridine
EC Number:
205-793-9
EC Name:
Aziridine
Cas Number:
151-56-4
Molecular formula:
C2H5N
IUPAC Name:
aziridine

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
other: poultices
Vehicle:
not specified
Duration of exposure:
4 days
Doses:
No data
No. of animals per sex per dose:
2 groups of 10 animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
14 mL/kg bw
Based on:
test mat.

Any other information on results incl. tables

No more available data on the results.

Applicant's summary and conclusion

Interpretation of results:
other: Guinea pig is not the preferred species for classification.
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
LD50 = 14mg/kg
Executive summary:

A range finding toxicity test was carried out for ethyleneimine, as well as other substances. This is a preliminary investigation of range findings regarding the subacute toxicity. Further studies have to be done. In this report, ethyleneimine was found to have a LD50 of 14 mg/kg bw for guinea pigs. The method is not stated.