Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-793-9 | CAS number: 151-56-4
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance. It does not follow any guideline, as it is an observation related to exposure to chemicals.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
- Type of study / information:
- This is a report on the observation of chromosome damage in chemical workers.
- Endpoint addressed:
- genetic toxicity
- Principles of method if other than guideline:
- The chromosome analysis was carried out with lymphocites tested according to the method of Moorhead slightly modified.
- GLP compliance:
- no
Test material
- Reference substance name:
- Aziridine
- EC Number:
- 205-793-9
- EC Name:
- Aziridine
- Cas Number:
- 151-56-4
- Molecular formula:
- C2H5N
- IUPAC Name:
- aziridine
Constituent 1
Method
- Ethical approval:
- not applicable
- Exposure assessment:
- measured
- Details on exposure:
- Observations were done in chromosomes of workers exposed to ethyleneimine from some months to 23 years. Since 1966, regular analysis of the air always revealed a value of less than 0.5 ppm ethylenimine.
Results and discussion
- Results:
- Healthy control subjects presented a certain percentage of spontaneous chromosome aberrations.
The percentage of chromosome aberration for workers exposed to ethyleneimine was 1-4%, not higher than the spontaneous chromosome aberrations.
Any other information on results incl. tables
No more available data on the results.
Applicant's summary and conclusion
- Conclusions:
- The percentage of chromosome aberration for workers exposed to ethyleneimine was 1-4%, not higher than the spontaneous chromosome aberrations.
- Executive summary:
This paper refers to the chromosome study carried out in chemical workers, exposed to different substances (ethyleneimine among them).
The investigations were recorded on chromosome damage of workers exposed to ethyleneimine from some months to 23 years. Since 1966, regular analysis of the air always revealed a value of less than 0.5 ppm ethylenimine. Healthy control subjects presented a certain percentage of spontaneous chromosome aberrations.
The percentage of chromosome aberration for workers exposed to ethyleneimine was 1-4%, not higher than the spontaneous chromosome aberrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
