Registration Dossier
Registration Dossier
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EC number: 242-538-0 | CAS number: 18727-04-3
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (16d, survival) = 0.25 mg cobalt hydrogencitrate/L (Brachydanio rerio) (read-across from cobalt chloride hexahydrate)
Key value for chemical safety assessment
Additional information
No data on long-term toxicity to fish are available for cobalt hydrogen citrate. However, there are reliable data available for different analogue substances.
The environmental fate pathways and ecotoxicity effects assessments for cobalt metal and cobalt compounds is based on the observation that adverse effects to aquatic, soil- and sediment-dwelling organisms are a consequence of exposure to the bioavailable ion, released by the parent compound. The result of this assumption is that the ecotoxicology will be similar for all soluble cobalt substances used in the ecotoxicity tests. Therefore, data from soluble cobalt substances are used in the derivation of ecotoxicological and environmental fate endpoints, based on the cobalt ion.
Data on chronic single-species toxicity tests resulting in high quality NOEC/L(E)C10 values (expressed as Co) for freshwater fish (n= 21) are summarised in the WHO CICAD, 2006 (see attached table).Chronic data for several different fish species were extracted and used in the effects assessment. The NOEC/L(E)C10 values for fish range from 60 μg Co/L for Brachydanio rerio to 2000 μg Co/L for Pimephales promelas (WHO CICAD, 2006), resulting in recalculated values from 0.25 to 8.45 mg cobalt hydrogencitrate/L. The most sensitive data for Brachydanio rerio are reported in detail as key study record (Dave and Xiu, 1991). In this study conducted to methods comparable to guidelines, a NOEC (16d) of 60 µg Co/L (tested as cobalt chloride hexahydrate) was obtained for survival, equivalent to 0.25 mg cobalt hydrogencitrate/L. Further results from studies on other freshwater fish are comprised in the attached table.
References: World Health Organization (2006). Concise International Chemical Assessment Document 69. COBALT AND INORGANIC COBALT COMPOUNDS.
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