Registration Dossier
Registration Dossier
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EC number: 271-653-9 | CAS number: 68603-38-3 This substance is identified by SDA Substance Name: C16-C18 and C18 unsaturated alkyl carboxylic acid amide diethanol and SDA Reporting Number: 11-024-00.
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Based on read-across to amides, C12-18(even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl), the 28 day NOEC of amides, C12, N,N-bis(hydroxyethyl) is considered to be equivalent to 0.32 mg/L (nominal in rainbow trout (i.e., equivalent to a measured concentration of 0.26 mg/L).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.26 mg/L
Additional information
A study was carried out to determine the effects on mortality, signs of intoxication and growth following exposure to structurally similar amides, C12-18(even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl) in rainbow trout for 28 days. The study was conducted according to OECD guidelines 204 and 215.
Ten fish per vessel was exposed to the test material at 0.032, 0.10, 0.32, 1.0 and 3.2 mg/L under flowthrough conditions. Mortality and symptoms of intoxication were observed daily and the growth parameters (i.e., body length and weight) were observed on Days 0 and 28.
At the highest nominal test concentration, all fish were dead after one day. At 1.0 mg/L, all fish showed clear symptoms of intoxication and died by Day 25. No significant effect on mortality or signs of intoxications were observed up to 0.32 mg/L. Furthermore, the mean body length and body wet weight of surviving fish were not significantly reduced compared to the control up to and including 0.32 mg/L. Growth rates at higher concentrations could not be determined due to mortality.
Under the test conditions, the NOEC and LOEC of the test substance for mortality, symptoms of intoxication and effects on growth was established at nominal concentrations of 0.32 and 1.0 mg/L (i.e., equivalent to a measured concentration of 0.26 and 0.83 mg/L), respectively, in rainbow trout. The lowest lethal concentration was established at 1.0 mg/L (i.e., equivalent to a measured concentration of 0.83 mg/L).
(Memmert U, 1995a).
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