Registration Dossier
Registration Dossier
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EC number: 221-659-2 | CAS number: 3179-63-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-dimethylaminopropan-1-ol
- EC Number:
- 221-659-2
- EC Name:
- 3-dimethylaminopropan-1-ol
- Cas Number:
- 3179-63-3
- Molecular formula:
- C5H13NO
- IUPAC Name:
- 3-(dimethylamino)propan-1-ol
- Details on test material:
- Name of the test substance used in the study report: N,N-Dimethyl-propanolamin
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- The test substance was given as a 1.5 or 3 % aqueous solution.
- Doses:
- 147, 215, 316 µl/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 177 mg/kg bw
- Remarks on result:
- other: original value is 200 µl/kg
- Mortality:
- 147 µl/kg: no deaths
215 µl/kg: 3/5 males and 3/5 females after 14 days
316 µl/kg: 5/5 males and 4/5 females after 14 days - Clinical signs:
- dyspnoea, spastic gait, slight tremor, slight apathy, partly clotted eyes
- Body weight:
- normal body weight growth, mean body weight of male animals = 28.5 g; mean body weight of female animals = 26.6 g
- Gross pathology:
- intensily intraabdominal agglutinations
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
