3-dimethylaminopropan-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented publication which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-dimethylaminopropan-1-ol

EC Number:

221-659-2

EC Name:

3-dimethylaminopropan-1-ol

Cas Number:

3179-63-3

Molecular formula:

C5H13NO

IUPAC Name:

3-(dimethylamino)propan-1-ol

Details on test material:

Name of the test substance used in the study report: N,N-Dimethyl-propanolamin

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: the test substance was administered as a 15 - 35% aqueous solution.

MAXIMUM DOSE VOLUME APPLIED:
10000 ul/kg

Doses:

1470, 2150, 3160, 6810, 10000 µl/kg (1299, 1900, 2793, 6020, 8840 mg/kg)

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 860 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 2 100 other: µl/kg bw

Based on:

test mat.

Remarks on result:

other: original value

Mortality:

1470 µl/kg: no deaths after 7 days
2150 µl/kg: 2/5 males and 3/5 females after 7 days
3160 µl/kg, 6810 µl/kg and 10000 µl/kg: all animals died within 7 days

Clinical signs:

other: dyspnoea, slight staggering, partly ventral position, apathy, reddished salivary secretion.

Gross pathology:

acute dilatation of the heart, congestive hyperemia, distinct diffuse reddening especially in the glandular stomach, partly bloody slough eschar formation, hematinized diarrheic intestine content.