3-dimethylaminopropan-1-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented publication which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Method: BASF-Test: Test was performed in principle as described in OECD Guideline 403.
The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20°C). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder for 8h. The documentation of clinical signs was performed over a period of 7 days. In order to verify the results, the test was repeated once.

GLP compliance:

no

Test type:

other: Inhalation-risk test (IRT)

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-dimethylaminopropan-1-ol

EC Number:

221-659-2

EC Name:

3-dimethylaminopropan-1-ol

Cas Number:

3179-63-3

Molecular formula:

C5H13NO

IUPAC Name:

3-(dimethylamino)propan-1-ol

Details on test material:

Name of the test substance used in the study report: N,N-Dimethyl-propanolamin

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Remarks on duration:

3 and 8 hours

Concentrations:

saturated vapour at 20 ºC (0.12 mg/L)

No. of animals per sex per dose:

6 for 3-h inhalation, 3 for 8-h inhalation

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: days 1 and 7
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

discriminating conc.

Effect level:

other: saturated vapour at 20 ºC

Based on:

test mat.

Exp. duration:

3 h

Remarks on result:

other: none of the animals died

Effect levels 2

Sex:

male/female

Dose descriptor:

discriminating conc.

Effect level:

other: saturated vapour at 20 ºC

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: 1 out of 6 animals died

Effect levels 3

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 0.12 mg/L air

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: theoretical value, calculated based on vapour pressure

Effect levels 4

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 0.06 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: theoretical value, calculated based on vapour pressure

Mortality:

3-hour exposure: 0/12; 8-hour exposure: 1/6

Clinical signs:

other: diffuse mucosa irritation, dyspnoea, diffuse corrosion

Body weight:

3-h epxosure: 243 g; 8-h exposure: 212 g

Gross pathology:

acute dilatation of the heart (especially on the right), spot-shaped hyperamie of the lung