Registration Dossier
Registration Dossier
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EC number: 253-455-4 | CAS number: 37310-83-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with the Guidance on Information Requirements and Chemical Saftey Assessment, chapter R.7c (ECHA, 2008) the profile on basic toxicokinetics of the reaction product of oleyl alcohol with polyphosphoric acid was derived from its physico-chemical data and toxicological data.
Due to its physico-chemical properties, primarily the low water solubility, and the absence of systemic toxicity in acute and subacute studies the oral absorption is expected to be negligible.
Based on its physico-chemical properties and absence of toxicity in an acute dermal toxicity study very limited absorption into the systemic circulation is expected after dermal application.
Considering the very low vapour pressure, the resulting low volatility of the high viscous liquid it is unlike that the substance will be inhaled either in vapour form or as dust particles under use conditions.
Since the absorption is expected to be very low the assessment of distribution, metabolism, accumulating potential and excretion of the poorly water soluble reaction product of oleyl alcohol with polyphosphoric acid is not considered to be relevant. According to this no signs of systemic toxicity and no target organs were observed in acute and subacute toxicity studies in rats.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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