Registration Dossier
Registration Dossier
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EC number: 295-118-4 | CAS number: 91844-53-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: QSAR Database
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July 2008
- Principles of method if other than guideline:
- Dermwin v2.01 (Q)SAR database report
Test material
- Reference substance name:
- Sorbitan, octanoate (2:3)
- EC Number:
- 295-118-4
- EC Name:
- Sorbitan, octanoate (2:3)
- Cas Number:
- 91844-53-0
- Molecular formula:
- Not available for UVCB
- IUPAC Name:
- Sorbitan, octanoate (2:3)
Constituent 1
Results and discussion
- Absorption in different matrices:
- Dermal absorption of the test substance was predicted to be very low to moderate with an estimated dermal permeability coefficient (Kp) of 0.000163 (C8 mono), 0.000511 (C10 mono), 0.0135 (C8 di), and 0.132 (C10 di) cm/hr and a dermal absorption rate of 0.006 mg/cm²/h (=0.0015 mg/cm²/event, C8 mono), 0.00022 mg/cm²/h (=0.00056 mg/cm²/event, C10 mono), 0.000082 mg/cm²/h (=0.0000206 mg/cm²/event, C8 di) and 0.000012 mg/cm²/h (=0.000003 mg/cm²/event, C10 di).
Applicant's summary and conclusion
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