Registration Dossier
Registration Dossier
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EC number: 224-339-0 | CAS number: 4316-74-9
Endpoint summary
Administrative data
Description of key information
According to the calculation by the EPI Suite by using the models BioWin3 and BioWin5, the criteria for readily biodegradable are BioWin3: weeks or faster and BioWin5: probability is >= 0.5. For sodium N-methyltaurinate, the result of BioWin3 is weeks while the result of BioWin5 is < 0.5. Therefore, the substance should be classified as not readily biodegradable.
However, further empirical studies show that the read-across substance N-methyltaurine is readily biodegradable according to an OECD 301C guideline study (62 % BOD after 28 days). N-methyltaurinate is the deprotonated form of N-methyltaurine. Both sodium N-methyltaurinate and N-methyltaurine are highly soluble in water. Therefore, it is expected that both substances can be degraded by comparable mechanisms in aqueous solution. Hence, the data on N-methyltaurine provide a reasonable measure for the biodegradability of sodium N-methyltaurinate. We conclude that sodium N-methyltaurinate is readily biodegradable. This result is also supported by further read-across substances.
Additional information
According to the calculation by the EPI Suite by using the models BioWin3 and BioWin5, the criteria for readily biodegradable are BioWin3: weeks or faster and BioWin5: probability is >= 0.5. For sodium N-methyltaurinate, the result of BioWin3 is weeks while the result of BioWin5 is < 0.5. Therefore, the substance should be classified as not readily biodegradable.
The guideline study according to OECD 301C shows that the read-across substance N-methyltaurine is readily biodegradable (62 % BOD after 28 days). This result is supported by the two guideline studies according to OECD 301B, which show that the read-across substances sodium N-methyl oleoyl taurinate and sodium N-methyl cocoyl taurinate, derivatives are readily biodegradable. This is supported by the handbook data of the J-CHECK database on sodium methyl oleoyl taurate. Further data on N-methyltaurine published by Levine et al. describe the substance to be rapidly biodegradable by plant rhizosphere microbes, although the biodegradation rate is not reported. N-methyltaurinate is the deprotonated form of N-methyltaurine. Both sodium N-methyltaurinate and N-methyltaurine are highly soluble in water. Hence, it is expected that both substances can be degraded by comparable mechanisms in aqueous solution. Therefore, the experimental OECD guideline study on N-methyltaurine provides a reasonable measure for the biodegradability of sodium N-methyltaurinate. In conclusion, sodium N-methyltaurinate is readily biodegradable.
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