Registration Dossier
Registration Dossier
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EC number: 423-340-5 | CAS number: 162881-26-7 CGI 819
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data are available regarding the toxicokinetic behavior and metabolism of the test substance.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No experimental data are available regarding the toxicokinetic behavior and metabolism of the test substance.
Due to its low water solubility and relatively large particle size, phenyl bis(2,4,6-trimethylbenzoyl)-phosphine oxide is considered to have low oral/ gastrointestinal absorption. It is expected this substance has no or very limited potential to be inhaled since it is insoluble in water, has low volatility and low vapour pressure. Based on the expected kinetic behaviour in the body, there is sufficient evidence that dermal absorption takes place and it is expected that uptake into the stratum corneum will be high. However, as there is no evidence of systemic toxicity in the 28-day oral toxicity study, the substance will likely not pass through the outer skin layer and hence, it will not pass through the rest of the skin and not enter the circulation. Phenyl bis(2,4,6-trimethylbenzoyl)-phosphine oxide will hardly be absorbed after oral and inhalation administration due to its hydrophobicity, relatively large particle size and low volatility as well as low vapour pressure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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