Registration Dossier
Registration Dossier
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EC number: 238-262-5 | CAS number: 14320-04-8
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
Pharmacokinetics and Body Distribution of Liposomal Zinc Phthalocyanine in Tumor-Bearing Mice: Influence of Aggregation State, Particle Size, and Composition (Isele U, et al 1995) Journal of Pharmaceutical Sciences Vol. 84, No. 2, February 1995
Upon intravenous administration, the dye is transported by lipoproteins [specifically, low-density lipoproteins (LDL)) to tumor tissues rich in lipoprotein receptors which internalize the dye-LDL complex by means of receptor-mediated endocytosis. After selective irradiation of the (epithelial) tumor with a laser light of the same wavelength as the absorption maximum of the dye, the ZnPc decomposes and the oxygen radicals formed in this photoactivation process kill the tumor cells. This so-called photodynamic therapy is being explored with hematoporphyrin as a photosensitizer in man for treatment of tumors of the esophagus, stomaeh, bladder, lung, skin, eye, and brain.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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