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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Old study, not to GLP, but similar to current guidelines

Data source

Reference
Reference Type:
publication
Title:
The Toxicity of Allylamines
Author:
Hine, CH, et al
Year:
1960
Bibliographic source:
Archives of Environmental Health, Volume 1, Pages 343-352

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
Only 3 animals per dose
GLP compliance:
no
Remarks:
Old study
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allylamine
EC Number:
203-463-9
EC Name:
Allylamine
Cas Number:
107-11-9
Molecular formula:
C3H7N
IUPAC Name:
prop-2-en-1-amine
Test material form:
other: liquid
Details on test material:
Molecular weight: 57.09
Boiling point: 52.9 deg C
Melting point: -88.2 deg C
Flash point, tag open cup: -20 deg F
Specific Gravity, 20/4 C: 0.7627
Solubility in water, 20 deg C, %W: complete
pH of 0.1M aqueous solution: 11.2
ppm in 1 mg/mL: 429

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
Animals weighed 2.0-2.8 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: Back/flanks
- % coverage: Not stated
- Type of wrap if used: rubber
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped dry
- Time after start of exposure: several hours

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): neat material, as required
- Concentration (if solution): N/A

Duration of exposure:
Several hours
Doses:
13, 25, 50 and 100 mg/kg
No. of animals per sex per dose:
3 males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes, where possible
Statistics:
LD50 calculated by method of Weil, 1952.

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
35 mg/kg bw
Based on:
test mat.
Mortality:
13 mg/kg: 0/3
25 mg/kg: 0/3
50 mg/kg: 3/3 (4-24 hours)
100 mg/kg: (3-4 hours)
Clinical signs:
other: Considerable local erythema and oedema, progressing to eschar formation Deaths occurred with no preliminary sign but head drop
Gross pathology:
Premature decedents usually had fluid in the pleural cavity and dilation of the gastroenteric veins. Microscopically all had severely congested lungs.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category I
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was 35 mg/kg
Executive summary:

Mortality in male rabbits was:

13 mg/kg: 0/3

25 mg/kg: 0/3

50 mg/kg: 3/3 (4-24 hours)

100 mg/kg: (3-4 hours)