Registration Dossier
Registration Dossier
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EC number: 282-208-3 | CAS number: 84144-87-6 Flue dust and ash containing vanadium resulting from the combustion of vanadium-bearing fuel oil.
Endpoint summary
Administrative data
Description of key information
Skin corrosion was assessed in a human skin in vitro assay (EpiSKIN) according to OECD 431 (Chelab 2010a). Skin irritation was assessed in a human skin model (EpiSKIN) according to the OECD draft proposal for new guideline: “in vitro skin irritation: human skin model test” (Chelab 2010b). In vivo skin irritation was assessed in New Zealand White rabbits according to OECD 404 (Chelab 2010c).
The eye irritating properties were assessed in vitro according OECD 437 (BSL 2010b).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The test material has been tested negative in two in vitro tests. In a subsequent acute dermal irritation study, 3 male New Zealand White rabbits were dermally exposed to 0.5 g of undiluted Vanadium Concentrate for 4 h to approximately 6 cm2of shaved, intact skin on both, back and hips. The test substance was administered semi-occlusive. After removal, the animals have been inspected for erythema and/or edema after 1, 24, 48, and 72 h. In all treated and control sites no edema or erythema was observed. On the basis of the results, the test substance vanadium concentrate can be considered to be non-irritant to the skin. This study is acceptable and satisfies the OECD guideline requirement for an acute dermal irritation study.
In a Bovine Corneal Opacity and Permeabiliy Assay (BCOP) Vanadium concentrate was exposed in vitro to 3 corneas for 4 h. The mean in vitro score was calculated to be 9.048. Therefore, Vanadium concentrate is considered to be mildly irritating to the eye.
Effects on eye irritation: irritating
Justification for classification or non-classification
Skin irritation properties were assessed in a standard in vitro/in vivo test battery. The test material was found to be non-irritant to the skin. According to an in vitro eye irritation assay (BCOP) the test substance shows mild irritation to the eye.
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