Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- adopted July 27, 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- 2008
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Version / remarks:
- August 1996
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -1.22
- Temp.:
- 20 °C
- pH:
- ca. 5.35
- Details on results:
- The partition coefficient is defined as the ratio of the equilibrium concentrations of a dissolved item in a two phase system consisting two largely immiscible solvents. In the case of n-octanol and water:
Pow = c n-octanol / c water
The partition coefficient is dimensionless and usually given in form of its logarithm to base ten.
A partition coefficient was calculated from data of each run. Alto-gether six values were obtained. These six log Pow values deter-mined laid within a range of ± 0.3 units. - Conclusions:
- According to this study the logarithmic partition coefficient (n-octanol/water) of the test item was determined to be
- 1.22
using the shake flask method at 20 °C ± 0.4 °C. - Executive summary:
The partition coefficient was calculated based on the results of the analytical determination following a shake flask test according to OECD Guideline 107. The test item content was determined by via UPLC-UV. The log Pow was calculated for each run. The difference between the three different test variants was less than the given ± 0.3 log units. Therefore, the study is considered to be valid.
According to this study the logarithmic partition coefficient (n-octanol/water) of the test item was determined to be
- 1.22
using the shake flask method at 20 °C ± 0.4 °C.
Reference
Description of key information
According to this study the logarithmic partition coefficient (n-octanol/water) of the test item was determined to be - 1.22 using the shake flask method at 20 °C ± 0.4 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.22
- at the temperature of:
- 20 °C
Additional information
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