Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 619-020-1 | CAS number: 94361-06-5
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Nov 1998 to 16 Dec 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: CIPAC method MT 157.3 (water solubility: flask method)
- GLP compliance:
- yes
- Medium:
- other: Dichloromethane
- Solubility:
- 430 g/L
- Temp.:
- 25 °C
- Medium:
- acetone
- Solubility:
- 360 g/L
- Temp.:
- 25 °C
- Medium:
- ethyl acetate
- Solubility:
- 240 g/L
- Temp.:
- 25 °C
- Medium:
- other: Hexane
- Solubility:
- 1.3 g/L
- Temp.:
- 25 °C
- Medium:
- methanol
- Solubility:
- 410 g/L
- Temp.:
- 25 °C
- Medium:
- n-octanol
- Solubility:
- 100 g/L
- Temp.:
- 25 °C
- Medium:
- toluene
- Solubility:
- 100 g/L
- Temp.:
- 25 °C
- Test substance stable:
- yes
- Conclusions:
- The solubility in seven different organic solvents has been determined ranged from 1.3 g/L in hexane to 430 g/L in dichloromethane.
- Executive summary:
The solubility of test substance has been determined in seven organic solvents. As there is no general method available for the determination of the solubility in organic solvents, a procedure similar to that described in CIPAC method MT 157.3 (water solubility: flask method) was used in this study in compliance with GLP. The solubility was found to range 1.3 g/L in hexane to 430 g/L in dichloromethane.
Reference
RESULTS
Table 1 Experimental data
| Aceton | Weight of test substance (g) dispersed in 20 mL solvent |
15.39 | |||||||||||
| Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
| Solubility (g/L) | 353 | 361 | |||||||||||
| Average (g/L) | 360 | ||||||||||||
| Dichloromethane | Weight of test substance (g) dispersed in 20 mL solvent |
20.96 | |||||||||||
| Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
| Solubility (g/L) | 443 | 422 | |||||||||||
| Average (g/L) | 430 | ||||||||||||
| Ethyl acetate | Weight of test substance (g) dispersed in 20 mL solvent |
16.06 | |||||||||||
| Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
| Solubility (g/L) | 239 | 242 | |||||||||||
| Average (g/L) | 240 | ||||||||||||
| Hexane | Weight of test substance (g) dispersed in 20 mL solvent |
1.00 |
|||||||||||
| Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
| Solubility (g/L) | 1.35 | 1.34 | |||||||||||
| Average (g/L) | 1.3 | ||||||||||||
| Methanol | Weight of test substance (g) dispersed in 20 mL solvent |
20.19 | |||||||||||
| Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
| Solubility (g/L) | 404 | 412 | |||||||||||
| Average (g/L) | 410 | ||||||||||||
| Octanol | Weight of test substance (g) dispersed in 20 mL solvent |
7.59 | |||||||||||
| Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
| Solubility (g/L) | 99 | 100 | |||||||||||
| Average (g/L) | 100 | ||||||||||||
Description of key information
The test substance can be considered miscible in organic solvents and ranged from 1.3 g/L in hexane to 430 g/L in dichloromethane, CIPAC MT 157.3, Stulz 1998.
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 1.3 g/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
