Registration Dossier
Registration Dossier
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EC number: 230-256-0 | CAS number: 6990-06-3
Endpoint summary
Administrative data
Description of key information
Fusidic acid is most stable to hydrolysis at pH =4. Above pH 4, the stability decreases with increasing pH. Less than 1% fusidic acid was degraded after 14 days in mixtures of acetonitrile and isotonic buffer, pH =7.4 (1:1) at 25+/-2°C.
For environmental realistic conditions at pH 7-8, fusidic acid will be almost completely (99-100%) dissociated and will be present in the fusidate form. Due to the dissociation of the substance, it is therefore justified to use environmental data on the fusidate form to describe fusidic acid under these conditions.
Fusidic acid is readily biodegradable. According to the ready biodegradation test OECD guideline No 301B (Fraunhofer Institute, 2019), 86% was degraded at the end of the 10 -day window, with a 94% biodegradation at test end observed for Na-fusidin.
This is similarly supported by observations in a 28 -day Semi-continuously Activated Sludge study showing that approximately 94% of fusidic acid was removed during a daily operating cycle.
Adsorption of fusidic acid to soil is estimated to be low, based on a Log Koc of 3.0.
Additional information
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