Registration Dossier
Registration Dossier
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EC number: 221-394-2 | CAS number: 3085-30-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- standard work on toxicology
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 1-Butanol in Patty's Industrial Hygiene and Toxicology (3rd rev ed)
- Author:
- Clayton (ed)
- Year:
- 1 982
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology (3rd rev ed)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no details provided
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Butan-1-ol
- EC Number:
- 200-751-6
- EC Name:
- Butan-1-ol
- Cas Number:
- 71-36-3
- Molecular formula:
- C4H10O
- IUPAC Name:
- butan-1-ol
Constituent 1
Test animals
- Species:
- rabbit
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 200 mg/kg bw
Any other information on results incl. tables
An additional result in the same publication gave an LD50 of 5300 mg/kg bw in rabbits
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 in rabbits is between 4200 and 5300 mg/kg bw.
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