Registration Dossier
Registration Dossier
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EC number: 612-975-5 | CAS number: 6225-08-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N,N-dimethyldecan-1-amide
- EC Number:
- 238-405-1
- EC Name:
- N,N-dimethyldecan-1-amide
- Cas Number:
- 14433-76-2
- Molecular formula:
- C12H25NO
- IUPAC Name:
- N,N-dimethyldecanamide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: russian
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml
- Observation period (in vivo):
- up to 21 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.6
- Max. score:
- 3
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.8
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The eye irritation property of N,N-Dimethylalkyl(C10)amide was investigated according to the Guideline OECD 405. Clear adverse effect on the eyes was observed that was reversible within 21 days.
- Executive summary:
The eye irritation property of N,N-Dimethylalkyl(C10)amide was investigated according to the Guideline OECD 405.
0.1ml of N,N-Dimethylalkyl(C10)amide was applied to the one eye of each three rabbits and observed for up to 21 days.
The calculated scores (average of 24h, 48h and 72h) are: cornea opacity 1.0, iritis 0.0, conjunctivia redness 2.6 and chemosis 2.8. Effects observed were reversible within 21 days.
N,N-Dimethylalkyl(C10)amide is to be classified as eye irritant.
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