Registration Dossier
Registration Dossier
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EC number: 817-668-1 | CAS number: 667899-24-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2/12/2015 to 1/3/2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- Storage condition of test material: at room temperature
- Key result
- Water solubility:
- 0.669 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- > 6.8 - < 6.9
- Details on results:
- The content of test substance dissolved in the water sample was 6.99E-7 g/L (0.699 μg/L). The coefficient of variation (CV) (n = 7 at 24 mL/h and n = 9 at 12 mL/h) was ≤ 30% at both flow rates. It demonstrated that the system was equilibrated at all flow rates.The maximum difference (MD) on the mean values of the samples at both flow rates was also ≤ 30%. Based on this, the water solubility of the test substance is given as the mean value of these measurements.The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates. A small test substance response was detected in the samples from the blank column. Since no test substance was observed in the duplicate (set of) blank sample(s), it was considered to derive from a contamination during sample treatment.
- Conclusions:
- The water solubility of the test substance at 20°C was determined to be 6.69E-7 g/L (0.669 μg/L) at pH of 6.8 – 6.9.
- Executive summary:
The water solubility of the test substance was determined according to EU Method A.6 and OECD Guideline 105. The column elution method was applied for the determination of the water solubility of the test substance. Under the test conditions, the water solubility of the test substance item at 20°C was 0.669 μg/L at pH of 6.8 – 6.9 (Lammers, 2016).
Reference
Description of key information
The water solubility was determined according to EU Method A.6 and OECD Guideline 105 (Lammers, 2016).
Key value for chemical safety assessment
- Water solubility:
- 0.669 µg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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