Registration Dossier
Registration Dossier
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EC number: 219-168-3 | CAS number: 2379-79-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-Testing method
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(1-aminoanthraquinon-2-yl)anthra[2,3-d]oxazole-5,10-dione
- EC Number:
- 219-168-3
- EC Name:
- 2-(1-aminoanthraquinon-2-yl)anthra[2,3-d]oxazole-5,10-dione
- Cas Number:
- 2379-79-5
- Molecular formula:
- C29H14N2O5
- IUPAC Name:
- 2-(1-aminoanthraquinon-2-yl)anthra[2,3-d]oxazole-5,10-dione
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: single
- Diet: Altromin standard diet ad libitum
- Water: tap ad libitum
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Remarks:
- 50% aq. solution
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- Back: 20 hours
- Observation period:
- 24 h, 8 d
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: back
SCORING SYSTEM:
Erythema and Edema
Ø - no effect
(+) - questionable
+ - mild
++ - moderate
+++ - marked
N - necrosis
Sch - scabbing
Na - scar
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 d
- Remarks on result:
- other: slight scabbing within 8 days
- Irritant / corrosive response data:
- Slight scabbing within 8 days
No erythema, edema or other signs of irritation/corrosion observed - Other effects:
- No evaluation at 24 h due to strong discolouration
Any other information on results incl. tables
Parameters evaluated:
reddening, edema, scabbing, necrosis, scarification
Descriptors:
questionable, minimal, moderate, marked, without effect
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The test item is not irritating to skin (rabbit). Slight scabbing occured within an observation period of 8 days.
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