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EC number: 220-293-0 | CAS number: 2706-28-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: modelling database
- Principles of method if other than guideline:
- ECOSAR v1.00
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: fish
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- no data
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 121 000 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 121000 mg/l on fish for substance Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate (Synonym of C.I. Acid Yellow 9) with mortality effects.
- Executive summary:
Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 121000 mg/l on fish for substance Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate (Synonym of C.I. Acid Yellow 9) with mortality effects.
Based on the lethal concentration for test substance Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate (Synonym of C.I. Acid Yellow 9) it is concluded that the test substance is non toxic to fish and thus not consider for the aquatic classification as per the CLP criteria.
Reference
Description of key information
Short term aquatic toxic effects of the test compound disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate was predicted (predicted model ECOSAR Version 1.10). The study was based on the effects of the test compound on the fish in 96 hrs duration in a fresh water system. The predicted data suggests the lethal concentration (LC50) on the basis of mortality to be 121000 mg/L. This value concluded that the test compound disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate does not exhibit short term toxicity to fish and is non hazardous to the aquatic environment.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 121 000 mg/L
Additional information
Short term toxicity to fish was assessed for the target compound disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate (CAS no 2706-28-7) and its related read- across by reviewing a number of studies. The summary of the results are presented below:
Short term aquatic toxic effects of the test compound disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate was predicted (predicted model ECOSAR Version 1.10). The study was based on the effects of the test compound on the fish in 96 hrs duration in a fresh water system. The predicted data suggests the lethal concentration (LC50) on the basis of mortality to be 121000 mg/L. This value concluded that the test compound disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate does not exhibit short term toxicity to fish and is non hazardous to the aquatic environment.
Whereas experimental study (Chemophere. Vol. 28, No. 12, pp. 2203.2236, 1994) for read across substance 2,2'-(1,2-Ethenediyl)bis(5-aminobenzenesulfonic acid) disodium salt (Cas no. 7336-20-1)indicate that the lethal concentrations i.e LC0 of test substance for fish Leuciscus idus, Bruchydunio rerio,Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate was found to be >1000 mg/l respectively for 72 hrs.
And other experimental study for read across Sodium 4,4'-diaminostilbene-2,2'-disulphonate (Cas no. 25394-13-2)indicate that the lethal concentration i.e LC50 of test substance on fish was found to be >200 mg/l for 48 hrs.( Data bank of Environmental Properties of Chemicals (EnviChem), 2016.)
Based on above available studies for target chemical and its read across it is concluded that the substance disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate (CAS no 2706-28-7) not qualify for the aquatic classification as per the CLP criteria.
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