Registration Dossier
Registration Dossier
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EC number: 207-622-3 | CAS number: 485-71-2
Endpoint summary
Administrative data
Description of key information
The read across substance quinine bisulphate has been used for a number of years as a clarifier of corneal opacities and to improve granular ophthalmia. Thus, it can be conclude that quinine is not irritating to eyes. We conclude that cinchonidine which differs in a methoxy group is also not irritating to eyes.
Additional information
Exposure related observations in humans:
Quinine bisulphate ointment has been used for a number of years as a clarifier of corneal opacities through its destruction of lymphocytes and leukocytes. In the two case reports a 2 % quinine bisulphate ointment was used post-operative to improve the regeneration. Furthermore, experiments have shown that quinine is one of the most effective antiseptics. Therefore, quinine bisulphate powder was used to improve granular ophthalmia. In all five case reports the eyes improved rapidly, the granulations became smaller and the intolerance of light disappeared completely within four days after using the quinine bisulphate powder. Thus, it can be conclude that the read across substance quinine is not irritating to eyes. We conclude that cinchonidine which differs in a methoxy group is also not irritating and does not need to be classified.
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