Registration Dossier
Registration Dossier
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EC number: 207-622-3 | CAS number: 485-71-2
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity of the read across substance cinchonidine hydrochloride to invertebrates:
the read-across substance cinchonidine hydrochloride was tested in astatic Daphnia magna, Acute Immobilisation Test according to the OECD Guideline 202 for 48 h. Five nominal concentrations between 26 and 100 mg/L were used. The EC50 of cinchonidine hydrochloride is 68.09 mg/L for Daphnia magna during the test period of 48 h. According to this, the EC50 of cinchonidine is 60.5 mg/L.
Short-term toxicity of the read across substance quinine to green algae:
In publication of Moreno-Garrido, 2001 the toxicity of the read across substance quinine sulphate to green algae Dunaliella salina was determined for 72 h in saltwater. The determined EC50 of quinine sulphate is 14.5 mg/L. According to this, the EC50 of quinine is 11.13 mg/L. We conclude that cinchonidine which differs in a methoxy group has a similar EC50 value.
Toxicity of cinchonidine to aquatic plants:
In the publication of Wink, 1992 the toxicity of cinchonidine to Lemna gibba was determined for 6 days. At a concentration of 0.4% cinchonidine lead to death. Bleaching of Lemna gibba was observed at a concentration of 0.04%.
Toxicity of cinchonidine to microorganisms:
In the study published by Wink, 1998 the bacterial growth inhibition of Bacillus subtilis, Escherichia coli and Serratia marcescens was determined. The IC100 of cinchonidine for E. coli is 3 mM (883.2 mg/L) and the IC100 for B. subtilis and S. marcescens is 10 mM (2.94 g/L). Cinchonidine has an antibacterial activity.
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