Registration Dossier
Registration Dossier
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EC number: 451-060-3 | CAS number: 122886-55-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2, 2003 - July 24, 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- (1992)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- (1989)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6
- Temp.:
- 24.5 °C
- Remarks on result:
- other: Pow of 1E06. Non-buffered mobile phase
- Details on results:
- - In the HPLC chromatogram of the test substance one peak was observed. The mean retention time was 63.58 minutes.
- Under the same conditions, the mean retention time of DDT (log Pow=6.2) was 25.3 minutes
- The mean retention time of formamide was 1.24 minutes - Conclusions:
- In a GLP-compliant study in accordance with EC A.8 and OECD 117 using the HPLC method, the log Pow of KY-UN has been determined as >6. The HPLC chromatogram of the test substance showed one peak; with a retention time > reference substance DDT (logPow=6.2).
Reference
Description of key information
The log Kow of KY-UN has been determined to be > 6 in a study according to OECD 117 (HPLC method).
The log Kow of KY-UN is 9.25 based on a KOWWIN (v1.68) calculation.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 9.25
- at the temperature of:
- 25 °C
Additional information
The log Kow of >6 was determined in a GLP-compliant study in accordance with EC A.8 and OECD 117 using the HPLC method. The HPLC chromatogram of the test substance showed one peak; with a retention time > reference substance DDT (logPow=6.2).
Calculation of the log Kow with KOWWIN (v1.68) gives a value of 9.25, which is considered as key value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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