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EC number: 208-762-8
CAS number: 540-97-6
Table 1 - Summary of Maternal Survival and Pregnancy Status
Females on study
Females that aborted or delivered
Females that diedfemales that aborted- nongravid- gravid
0 (0.0)0 (0.0)0 (0.0)0 (0.0)
Females that were euthanized- nongravid
0 (0.0)0 (0.0)
Females examined at scheduled - necropsy- nongravid- gravid- with resorptions only- with viable fetuses
22 (100.0)0 (0.0)22 (100.0)1 (4.5)21 (95.5)
22 (100.0)0 (0.0)22 (100.0)0 (0.0)22 (100.0)
Total females gravid
Table 2 - Summary of Fetal Data at Scheduled Necropsy
Post implantation loss
Pre implantation loss
Fetal weight (g)
No. of gravid females
Table 3 - Summary of Fetuses amd Litters Data
Number examined externallyNumber with findings
Number examined viscerallyNumber with findings
Number examined skeletally- polydactyly
- rib anomaly- sternebra, malaligned (slight/moderate)- sternebra, malaligned (severe)
- ossification , reduced skull
- vertebral centra, unossified
- bent limb bones
Total number with malformations- external- soft tissue- skeletal
A prenatal developmental toxicity study (OECD 414) of
Dodecamethylcyclohexasiloxane (D6) was carried out in rats by oral
gavage. Eighty-eight mated female Wistar Han rats were assigned to four
dose groups. The test item was administered undiluted once daily by oral
gavage from Days 6 to 20 post-coitum at doses of 0, 100, 330 and 1000
mg/kg bw/day (Groups 2, 3 and 4 respectively). The rats of the control
group received water at the same dose volume as Group 4 animals. Females
were checked daily for the presence of clinical signs. Food consumption
and body weight were determined at periodic intervals.
On Day 21 post-coitum, all animals were subjected to an examination
post-mortem and external, thoracic and abdominal macroscopic findings
were recorded. Terminal body and liver weights were recorded for each
dam and body weights gains were calculated. A laparohysterectomy was
performed on each dam of all groups. The uteri, placentae and ovaries
were examined, and the numbers of fetuses, early and late resorptions,
total implantations and corpora lutea were recorded. Gravid uterine
weights were recorded, and corrected body weights (changes) were
calculated. The fetuses were weighed, sexed and examined for external,
visceral and skeletal malformations and developmental variations. All
live fetuses were euthanized. One half of the fetuses were decapitated
and the heads were fixed in Bouin’s fixative, these fetuses were
dissected and examined for visceral anomalies. All fetuses were fixed in
96% aqueous ethanol and stained with Alizarin Red S and had skeletal
examinations performed. Histopathology was performed on the livers from
all dams of Groups 1 and 4.
At 1000 mg/kg bw/day, maternal animals had higher absolute and relative
liver weights. The difference from controls was slight but statistically
significant. There were no test item-related microscopic findings
observed during the histopathological evaluation, therefore, the
increases in liver weights were not considered toxicologically relevant.
No maternal toxicity was observed in the other parameters examined in
this study with treatment up to 1000 mg/kg bw/day (mortality, clinical
signs, body weights, food consumption and macroscopic examination). No
developmental toxicity was observed up to 1000 mg/kg bw/day groups.
The maternal and developmental NOAEL for D6 were established as being at
least 1000 mg/kg bw/day.
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