Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-762-8
CAS number: 540-97-6
Reliable data are available for toxicity to aquatic algae. A 72-hour EC50
value of >2.0 μg/L and NOEC of ≥2.0 μg/L have been determined for the
effects of the test substance on growth rate of Pseudokirchneriella
There are no data for short-term toxicity to fish. However, in
accordance with Column 2 specific rules for adaptation from Column 1 of
Annex VIII of the REACH Regulation, the study does not need to be
conducted because a long-term aquatic toxicity study on fish is
available for an appropriate read-across substance.
There are no data for short-term toxicity to aquatic invertebrates.
However, in accordance with Column 2 specific rules for adaptation from
Column 1 of Annex VII of the REACH Regulation, the study does not need
to be conducted because a long-term aquatic toxicity study on
invertebrates is available.
Reliable test results are available for
long-term toxicity to fish. A read-across 90-day NOEC of ≥14.4 μg/l has
been determined for the effects of the structurally similar substance
decamethylcyclopentasiloxane (D5, CAS 541-02-6) on early-life stages of Oncorhynchus
Reliable test results are available for long-term toxicity to aquatic
invertebrates. A 21-day NOEC of ≥4.6 µg/L has been determined for the
effects of the test substance on survival, growth and reproduction of Daphnia
The highest exposure concentrations utilised in the short- and long-term
tests were close to the functional solubility of the test substance in
the exposure media. It is therefore concluded that the substance is not
toxic to fish, invertebrates and algae following short- and long-term
exposure at its functional water solubility limit.
For aquatic sediment, NOEC values are available from three long term
tests with two species representing different living and feeding
conditions (Lumbriculus variegatus and Chironomus riparius). Assessment
of the registration substance and analogous siloxanes sediment toxicity
data set has revealed some apparently inconsistent and contradictory
In many different studies across the range of siloxanes with sediment
toxicity data available, the observations indicate in general no
effects, or an organic carbon normalised NOEC ≥30 mg/kg dwt.
This would be in-line with a general narcotic mode of action, observed
for other structural classes and effects in pelagic species. In some
cases, however, a significantly higher toxicity for a substance is
exhibited, resulting in very low NOEC values. Furthermore, in each case
where significantly higher toxicity was observed, an alternative study
is available in which much lower toxicity was measured in the same
species for the identical substance using natural sediment and with
lower pH (<8). Consideration of the possible contributing factors that
could have caused high toxicity in these studies, led to an
understanding of the importance of certain factors of the test design,
particularly the use of artificial sediment with a peat-based carbon
source, and elevated pH in the test system.
As a result, the reliability of the Chironomus riparius study for
the registration substance with artificial sediment (with peat based
carbon source) and high pH is considered not assignable.
The study with test species Lumbriculus
using natural sediment
reported a LOEC of >420 mg/kg dw sediment and a NOEC of ≥420
mg/kg dw sediment. The study
with Chironomus riparius,
conducted in natural sediment,
reported a NOEC of ≥620
A result for effects in natural sediment on the invertebrate amphipod Hyalella
azteca is read across from decamethylcyclopentasiloxane (D5, CAS
541-02-6). The result from that test is a 28 d EC50 value
of >130 mg/kg sediment dry weight for growth rate and a NOEC value of
130 mg/kg sediment dry weight (135 mg/kg dw normalised to 5% OC) for
The NOEC value normalised to 5% OC of 135 mg/kg dw sediment for effects
of the read-across substance D5 on Hyalella azteca is used as the
key value for the CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again