Registration Dossier
Registration Dossier
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EC number: 412-060-9 | CAS number: 136210-32-7 DESMOPHEN VP-LS 2973 E; DESMOPHEN VP-LS 2975 E; DESMOPHEN VP-LS 2985 E
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The potential of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester to sorb on soil or sediment was determined according to EU-Method C.19 (HPLC-Method) yielding a logKoc between 4.2 and 5.1. For environmental assessment a mean log Koc value of 4.7 (Koc 44668) was used (Bayer, 2003).
The sorption coefficient was determined at pH 6 and pH 8 showing that the sorption behaviour does not depend on the prevailing pH.
According to the classification of Swann et al. (1983), aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-,1,1',4,4'-tetraethyl ester has a high potential to sorb on soil.
Key value for chemical safety assessment
- Koc at 20 °C:
- 44 668
Additional information
The applied HPLC method as stipulated in the EU-method C.19 method is suitable to determine sorption coefficients for mixtures having logKoc values up to a value of 5. As the test substance is a mixture of stereoisomeric components, only an unresolved elution band was obtained. Consequently, a logKoc range was reported rather than a single value. In the underlying method, the calibration was based on standards with a maximal logKoc of 4. Thus, the logKoc of the test substance could solely be evaluated by linear extrapolation beyond the prescribed calibration range.
To comply with the requirements of the EU-guideline C.19 for the measurement of ionisable substances, the sorption coefficient was determined at pH 6 and pH 8. Aspartic acid, N,N'-[methylenebis(2 -methyl-4,1 -cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester as an organic base is partly ionised at pH 6 and non-ionised at pH 8. The pKa of the test substance was estimated prior to the experiment by the means of the software ACD/pKa v 6.0 to select the required pH values.
The determined sorption coefficient (logKoc) at pH 6 (ionised form) covers the range between 4.3 and 5.1, whereas the logKoc of the non-ionised form of this organic base ranges between 4.2 and 5.1. Based on these results it can be seen that the sorption behaviour does not depend on the prevailing pH.
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