Registration Dossier
Registration Dossier
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EC number: 407-550-4 | CAS number: 69184-17-4
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 April 1991-25 November 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
- Qualifier:
- according to guideline
- Guideline:
- other: EEC A7
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl O-(4-amino-3,5-dichloro-6-fluoropyridin-2-yloxy)acetate
- EC Number:
- 407-550-4
- EC Name:
- Methyl O-(4-amino-3,5-dichloro-6-fluoropyridin-2-yloxy)acetate
- Cas Number:
- 69184-17-4
- Molecular formula:
- Hill formula: C8 H7 Cl2 F N2 O3 CAS formula: C8 H7 Cl2 F N2 O3
- IUPAC Name:
- methyl 2-[(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetate
- Details on test material:
- - Name of test material (as cited in study report): Fluroxypyr methyl ester
- Physical state: white crystalline powder
- Analytical purity: 99.7% w/w
- Purity test date: 26.09.1990
- Lot/batch No.: AGR 279096
- Expiration date of the lot/batch: September 1992
- Storage condition of test material: below 5 °C
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubility
- Medium:
- standard fat
- Solubility:
- 26.5 other: g/kg
- Temp.:
- 37 °C
- Test substance stable:
- yes
- Details on results:
- Fat solubility: 26.5 ± 2.6 g/kg, coefficient of variation 9.9%.
Any other information on results incl. tables
Measurements of fat solubility at 37 °C:
Sample No. |
Time held at 30 °C (h) |
Time held at 50 °C (h) |
Time equilibrated at 37 °C (days) |
Conc. (g/kg) |
Mean conc. (g/kg) |
30C, 30D |
1 |
- |
2 |
23.3, 23.7 |
23.5 |
30E, 30F |
1 |
- |
3 |
25.3, 25.9 |
25.6 |
50C, 50D |
- |
1 |
2 |
59.7, 29.2 |
29.2 |
50E, 50F |
- |
1 |
3 |
28.2, 29.8 |
29.0 |
Determined as overall (pooled) method of all tests. Sampe 50C ommited from calculation due to anomalously high value.
Applicant's summary and conclusion
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