Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of mercaptobenzothiazole
- Author:
- Randall, D., J.; et al.
- Year:
- 1 990
- Bibliographic source:
- Journal of American College of Toxicology, part B, vol.1, 62
Materials and methods
- Principles of method if other than guideline:
- other: eye irritation study
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- mercaptobenzothiazole (MBT), purity: 97.4 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 3.2
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: 24 h: slight to moderate erythema, moderate to copious discharge containing slight withish exudate
- Other effects:
- no effects
Any other information on results incl. tables
MBT was slightly and transient irritating to the rabbit eye, 3.2/110
After application:
Immediate: discomfort was slight
10 minutes: slight to moderate erythema, moderate to copious discharge
1 hour: slight to moderate erythema, copious discharge (mean score: 8.3/110.0)
24 hours: slight to moderate erythema, moderate to copious discharge containing slight whitish exudate (mean score: 8.6/110.0)
48 hours: gradual improvement (mean score: 1.0/110.0)
72 hours: all scored zero
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Classification: not irritating
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