Registration Dossier
Registration Dossier
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EC number: 229-761-9 | CAS number: 6711-48-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study was performed, comparable with OECD Guideline 403. However, documentation of information was very limited.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- EC Number:
- 229-761-9
- EC Name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- Cas Number:
- 6711-48-4
- Molecular formula:
- C10H25N3
- IUPAC Name:
- (3-{[3-(dimethylamino)propyl]amino}propyl)dimethylamine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): bis-dimethyl aminopropylamine; 3,3'-bis (dimethylamino) dipropylamine; bis (N,N'-dimethylaminopropoyl) amine
- Other: density: 0.84 g/L
Test animals
- Species:
- rat
- Strain:
- other: CF Nelson
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 160 g
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- Animals were exposed to near-saturated vapor
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7.25 h
- Concentrations:
- No data
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Remarks on result:
- other: Since no animal died
- Remarks:
- the LC50 was not derived
- Mortality:
- 0/6 animals died
- Clinical signs:
- other: No signs of intoxication observed
- Body weight:
- Mean body weight at termination: 212 g
- Gross pathology:
- Normal
Any other information on results incl. tables
Since no animals have died, no LC50 was derived.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, no animals died, no signs of intoxication were observed and gross autopsy was normal after exposure to near-saturated vapor for 7 1/4 hours at 23°C.
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