Registration Dossier
Registration Dossier
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EC number: 439-590-3 | CAS number: 12158-75-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A separate study on skin sensitization by Basic Copper Nitrate is deemed not necessary for scientific reasons and to avoid unnecessary animal experimentation. Instead, an extrapolation based on a study of Copper hydroxide was carried out for the following reasons:
(1) It is anticipated that the substance will disassociate to a certain degree upon contact with skin moisture and release nitrate and copper ions. Given the low water solubility and the assumption that the nitrate ions will remain neutral in this context, it is recommendable to draw an analogy to similar scarcely soluble copper compounds.
(2) In a report on a maximization test by Magnusson & Kligmann involving 20 test subjects and 20 controls (Final Report on Skin Sensitization IBR 1992 Project N° 10-05-0714/00-92), no signs of skin sensitization were observed at any time in any of test animals.
Consequently, there is no concrete reason for believing that copper ions which can be released from Basic Copper Nitrate will have a skin-sensitizing effect.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
No data available
Justification for classification or non-classification
Based on a maximization test carried out on Copper hydroxide, Basic Copper Nitrate is not to be classified as skin sensitizer.
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