Registration Dossier
Registration Dossier
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EC number: 218-644-8 | CAS number: 2210-74-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Experimental data by the Supplier.
Test method: OECD Guideline for the Testing of Chemicals No. 209 "Activated Sludge, Respiration Inhibition Test", Method C.11 of Commission Regulation (EC) no.440/2008 and US EPA Draft Ecological Effects Test Guidelines OPPTS 850.6800.
The study was performed in compliance with the principles of the Good Laboratory Practice (GLP.
Experimental data: April 2011
Key value for chemical safety assessment
- EC50 for microorganisms:
- 650 mg/L
- EC10 or NOEC for microorganisms:
- 150 mg/L
Additional information
Activated sewage sludge was exposed to an aqueous solution of the test item at concentrations of 10, 32, 100, 320 and 1000 mg/l for a period of 3 hrs at a temperature of 21 °C with the addition of a synthetic sewage as a respiratory substrate.
the rate of respiration was determined after 3 hrs contact time and compared to data for the control and a reference item, 3,5 -dichlorophenol.
The effect of the test item on the respiration of activated sewage sludge gave a 3 -hr EC50 of 650 mg/l. The NOEC after 3 hrs exposure was 150 mg/l.
The reference item gave a 3 -hr EC50 value of 6.0 mg/l, 95% confidence limits 4.4 -8.1 mg/l.
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