Registration Dossier
Registration Dossier
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EC number: 248-440-4 | CAS number: 27394-99-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- BASF-Test: Mice were injected intraperitoneally with the test substance (three different concentrations used) and then observed for 14 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- N-(1-cyanoethyl)formamide
- EC Number:
- 248-440-4
- EC Name:
- N-(1-cyanoethyl)formamide
- Cas Number:
- 27394-99-6
- Molecular formula:
- C4H6N2O
- IUPAC Name:
- N-(1-cyanoethyl)formamide
- Details on test material:
- N-Formylalaninnitril (purity 98%)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- no data
- Doses:
- 50, 200, 700 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 200 - 700 mg/kg bw
- Mortality:
- Dose 700 mg/kg: 1 male animal died within 1 hour, 4 male animals died within 1 day; 4 female animals died within 1 day
- Clinical signs:
- Dose 200 mg/kg: dyspnoea, apathy, spastic gait, piloerection and a poor general state
Dose 700 mg/kg: dyspnoea, apathy, abnormal position, staggering, tremor, convulsions, exsiccosis, poor general state - Body weight:
- no data
- Gross pathology:
- In dead as well as sacrificed animals, no intraabdominal deposits or
conglutinations were observed.
Any other information on results incl. tables
The LD50 was determined to be > 200 and < 700 mg/kg bw.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
