Registration Dossier
Registration Dossier
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EC number: 247-728-7 | CAS number: 26479-35-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
An in vitro metabolism study, the stability of potassium allophonate was investigated when tested with rat S9 microsomal fraction both in the presence and absence of NADPH. Under both test conditions, complete conversion to urea was observed at time zero, indicating that conversion of potassium allophonate occurs prior to incubation in rat liver microsomes (i.e., occurs via hydrolysis). Based on the results of this test, it is clear that potassium allophonate has no potential to bioaccumulate in the human body.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
An in vitro metabolism study is available for potassium allophonate, the formation of urea after incubation of potassium allophonate in S9 rat liver microsomes was investigated (Ricerca Biosciences, 2013). Potassium allophonate was tested at a concentration of 10 μM and was incubated at 37 deg C in rat liver microsomes for 0, 10, 20, 30 and 60 minutes, in the presence and absence of reduced nicotinamide adenine dinucleotide phosphate (NADPH). The time zero sampling event (prior to addition of S9) showed that all potassium allophonate was converted to urea in both test systems, suggesting that conversion of potassium allophonate occurs prior to incubation in rat liver microsomes (i.e., occurs via hydrolysis). This was confirmed in stability tests using different ratios of the study vehicle, dimethyl sulfoxide (DMSO)/water. Based on the results of this test, it is clear that potassium allophonate has no potential to bioaccumulate in the human body.
References:
Ricerca Biosciences, LLC. 2013. Metabolic Stability of Potassium Allophonate and Formation of Urea in Rat Liver Microsomes. Testing laboratory: Ricerca Biosciences, LLC, Drug Safety and Metabolism, 7528 Auburn Road, Concord OH 44077. Report no.: 029722. Report date: 2013-03-01.
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