Registration Dossier
Registration Dossier
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EC number: 247-728-7 | CAS number: 26479-35-6
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis as a function of pH testing is not required for substances that are readily biodegradable. A study performed according to Organisation for Economic Co-Operation and Development (OECD) Test Guideline 301D found that potassium allophonate meets the criteria for ready biodegradability. Therefore, hydrolysis testing is waived in accordance with Column 2 of Annex VIII of Regulation (EC) No. 1907/2006.
Key value for chemical safety assessment
Additional information
In accordance with Column 2 of Annex VIII of Regulation (EC) No. 1907/2006, hydrolysis as a function of pH testing does not need to be completed if the substance is readily biodegradable. Potassium allophonate is readily biodegradable; therefore, hydrolysis testing is waived.
Supporting read-across to urea for (eco)toxicological endpoints, Cheng et al. (2005) found that potassium allophonate readily underwent decarboxylation (DT50 = 3 h) to exclusively form urea (CAS# 57 -13 -6) at acidic pH in the presence of 7.3 mM sodium phosphate buffer. A general trend of increased stability at alkaline pH and lower buffer concentration was observed. A hydrolysis study performed on potassium allophonate in a sodium phosphate buffer (pH 8.0), found that potassium allophonate was stable to hydrolysis (Ricerca Biosciences, 2013), supporting the findings of Cheng et al. (2005) of increased stability at alkaline pH.
References:
Cheng, G., Shapir, N., Sadowsky, M. J. and Wackett, L. P. 2005. Allophonate hydrolase, not urease, functions in bacterial cyanuric acid metabolism. Applied and Environmental Microbiology, 71(8): 4437 -45.
Ricerca Biosciences, LLC. 2013. Metabolic Stability of Potassium Allophonate and Formation of Urea in Rat Liver Microsomes. Testing laboratory: Ricerca Biosciences, LLC, Drug Safety and Metabolism, 7528 Auburn Road, Concord OH 44077. Report no.: 029722. Report date: 2013-03-01.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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