Registration Dossier
Registration Dossier
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EC number: 201-164-8 | CAS number: 78-98-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Two studies on reproduction toxicity are available. Both publications were disregarded because they were either published on very specific topic ( Amicarelli et at., 1993), or just an abstract briefly quoted in a textbook (Peters et al. 1977).
Additional information
No guideline compatible reproduction toxicity study assessing fertility is available.
In accordance with the REACH legislation only the available data have to be presented. A specific study is not required (Article 18 or Annex VII).
Effects on developmental toxicity
Description of key information
No guideline compatible reproduction toxicity study assessing developmental toxicity / teratogenicity is available.
Toxicity to reproduction: other studies
Additional information
Disregarded studies:
Amicarelli, F. et al., Adaptive response of human melanoma cells to methylglyoxal Injury. Chem.-Biol. Interact., 114, 177-189, 1998
Peters, M.A. et al., Toxicity of methyl glyoxal to pregnant and non-pregnant rats. Congress of Toxicology, Abstr., p. 528, 1977, quoted in Schardein, J.L., Miscellaneous Chemicals, in: Chemically Induced Birth Defects, p. 842-869, Marcel Dekker, N.Y., 1993
Justification for classification or non-classification
Based on the available studies on reproduction toxicity, a justification for the classification of pyruvaldehyde is not possible.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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